Arthur Ogendo, a researcher at the Kenya Medical Research Institute talks about his experience in developing demonstrative studies of PrEP in Kenya, targeting the most vulnerable population such as Men who have sex with men(MsM) and sex workers. He also reports challenges for implementing PrEP as a prevention program in that country. Ogendo hopes that the International AIDS Conference will bring progress with regard to provision of treatment and communication of PrEP to the most vulnerable populations, especially in developing countries.